Smad7 gene transfer inhibits peritoneal fibrosis
نویسندگان
چکیده
منابع مشابه
Treatment of established peritoneal fibrosis by gene transfer of Smad7 in a rat model of peritoneal dialysis.
BACKGROUND/AIMS It has been shown that blockade of TGF-beta1 signaling with Smad7 prevents experimental peritoneal fibrosis. The present study investigated whether Smad7 has a therapeutic effect on established peritoneal fibrosis associated with peritoneal dialysis (PD). METHODS A rat model of peritoneal fibrosis was induced by a daily intraperitoneal infusion of 4.25% Dianeal. After peritone...
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Transforming growth factor beta (TGF-beta) plays a critical role in the pathogenesis of the peritoneal fibrosis that complicates long-term peritoneal dialysis (PD). We studied the TGF-beta/Smad signaling pathway in peritoneal fibrosis induced in uremic rats treated with PD and explored the therapeutic potential of Smad7 to prevent fibrogenesis. After subtotal nephrectomy, uremic rats were treat...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2007
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002533